Relationship Between Hormonal Contraception History and Breast Cancer at RSUD Jenderal Ahmad Yani Metro City
DOI:
https://doi.org/10.31004/anthor.v5i2.396Keywords:
Hormonal Contraception, Breast Cancer, Contraceptive History, Women’s Health, Risk FactorsAbstract
Breast cancer remains a major global health threat, with WHO data from 2022 reporting 2.3 million cases and 670,000 deaths. Breast cancer is caused by uncontrolled cell growth and hormonal factors, and this disease affects physical and emotional conditions. This quantitative study with a case-control design at General Ahmad Yani Metro Hospital aims to determine the relationship between a history of hormonal contraception and breast cancer. This study involved 93 respondents (31 cases and 62 controls) selected through accidental sampling techniques from the Oncology Surgery and Internal Medicine Rooms. The results showed that 83.9% of respondents had a history of hormonal contraception use. Statistical analysis using the chi-square test and Odds Ratio showed a significant association (p-value = 0.036; OR = 8.750), indicating that this history is associated with a significantly higher risk of developing breast cancer. This study concluded that the use of hormonal contraception is associated with an increased risk of breast cancer, so education, early screening, and regular monitoring are needed, especially for long-term hormonal contraception users.
References
Adiputra, I. M. S., et al. (2021). Statistika kesehatan teori & aplikasi. Yayasan Kita Menulis.
American Cancer Society. (2022). Breast cancer facts and figures 2022–2024. American Cancer Society.
Aprilianty, D. A., Faridah, Suhrawardi, & Rusmilawaty. (2024). Studi literatur faktor risiko yang berhubungan dengan kejadian kanker payudara pada wanita. Jurnal Cakrawala Ilmiah.
Astuti, H., et al. (2023). Kesehatan reproduksi remaja dan lansia. Eureka Media Aksara.
Dahlan, M. S. (2010). Besar sampel dan cara pengambilan sampel. Salemba Medika.
Dinas Kesehatan Kota Metro. (2024). Profil kesehatan Kota Metro tahun 2023. Dinas Kesehatan Kota Metro.
Dinas Kesehatan Provinsi Lampung. (2024). Profil kesehatan tahun 2023. Pemerintah Provinsi Lampung.
Diskominfo Kota Metro. (n.d.). Walikota Metro tandatangani komitmen bersama gerakan peduli kanker serviks dan payudara. Informasi Pemerintah Kota Metro. https://info.metrokota.go.id/walikota-metro-tandatangani-komitmen-bersama-gerakan-peduli-kanker-serviks-dan-payudara/
Fadhila, S. R., Karyus, A., Setiaji, B., Irianto, S. E., Za’im, A., & Nonasri, F. G. (2024). Analisis faktor yang berhubungan dengan kanker payudara pada wanita di Klinik Bintang KI Maja Lampung. Malahayati Nursing Journal, 6, 1–23. https://doi.org/10.33024/mnj.v6i8.15890
Feriani, P., et al. (2023). Cancer risk factors associated with historical contraceptive use and breastfeeding duration. Healthcare in Low-Resource Settings, 11(2), 95–99. https://doi.org/10.4081/hls.2023.11812
Fitzpatrick, D., Pirie, K., Reeves, G., Green, J., & Beral, V. (2023). Combined and progestagen-only hormonal contraceptives and breast cancer risk: A UK nested case–control study and meta-analysis. PLoS Medicine, 20(3), 1–18. https://doi.org/10.1371/journal.pmed.1004188
Hall, J. E., & Guyton, A. C. (2019). Buku ajar fisiologi kedokteran (Vol. 11). Saunders Elsevier.
Hanifah, A. N., Kusumasari, H. A. R., & Jayanti, N. D. (2023). Konsep pelayanan kontrasepsi KB. Media Sains Indonesia.
Kana, Y. N. R., et al. (2024). Dasar kesehatan reproduksi. PT Sada Kurnia Pustaka.
Kementerian Kesehatan Republik Indonesia. (2023). Laporan tahunan 2022 pencegahan dan pengendalian penyakit tidak menular (PTM). Kementerian Kesehatan RI.
Kementerian Kesehatan Republik Indonesia. (2024). Hari kanker sedunia. Kementerian Kesehatan RI.
Kementerian Kesehatan Republik Indonesia. (2024). Profil kesehatan Indonesia 2023. Kementerian Kesehatan RI.
Kementerian Kesehatan Republik Indonesia. (n.d.). Pencegahan kanker payudara. Direktorat Jenderal Pelayanan Kesehatan. https://yankes.kemkes.go.id/view_artikel/3108/pencegahan-kanker-payudara
Kurniawati, T., Kurniati, L., Elliana, D., & Purwatianingsih, I. (2019). Hubungan lama penggunaan kontrasepsi hormonal dan umur dengan kejadian kanker payudara di RSUP Dr. Kariadi Semarang. Jurnal Ilmu Kebidanan dan Kesehatan, 10(1), 1–15.
Masrukhin. (2015). Statistik 1 aplikasi program Excel, Ministep (Winsteps) Rasch, SPSS, Amos, Warp-PLS. Media Ilmu Press.
Mustika, D. N., Kusumawati, E., & Istiana, S. (2016). Kesehatan reproduksi: Deteksi dini kanker serviks dan payudara. CV Rafi Sarana Perkasa.
Prihati, D. R., Paryono, & Rohmawati, W. (2022). Monograf kontrasepsi hormonal. Mitra Cendikia Media.
Savitri, A. (2019). Kupas tuntas kanker payudara, leher rahim & rahim. Pustaka Baru Press.
Sayyid, M. T. (2022). Studi pola penggunaan obat kemoterapi pada pasien kanker payudara di Rumah Sakit Umum Daerah (RSUD) Jenderal Ahmad Yani Metro periode Januari–Juni 2022. Jurnal Institut Teknologi Sumatera.
Setiati, E. (2009). Waspadai 4 kanker ganas pembunuh wanita. Andi.
Sugiyono. (2013). Metodologi penelitian kuantitatif, kualitatif dan R&D. Alfabeta.
Sung, H., et al. (2021). Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 71(3), 209–249. https://doi.org/10.3322/caac.21660
Suryani, Y. (2020). Kanker payudara. Freeline Cipta Granesia.
Syapitri, H., Amila, & Aritonang, J. (2021). Metodologi penelitian kesehatan. Ahlimedia Press.
WHO. (n.d.). Breast cancer. World Health Organization. https://www.who.int/news-room/fact-sheets/detail/breast-cancer
Widodo, S., Ladyani, F., & Asrianto, L. O. (2023). Buku ajar metode penelitian. Science Techno Direct.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Gebby Amadea, Septi Widiyanti, Prasetyowati, Firda Fibrila
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
